TreatING tardive dyskinesia (TD) with INGREZZA: See the results

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In clinical studies of INGREZZA® (valbenazine) capsules as a treatment for TD:

2 weeks, Icon
2 weeks, Icon

INGREZZA started working quickly for most people

In just 2 weeks, 64% of people taking INGREZZA started to experience fewer uncontrollable body movements.*

*In a 6-week clinical study. Post-clinical study evaluation of 149 patients who took 40 mg and/or 80 mg during the first 2 weeks; 64% had at least a 1-point reduction on an uncontrollable movement severity scale.

6 weeks, Icon
6 weeks, Icon

INGREZZA 80 mg significantly reduced TD at 6 weeks

Additionally, 7 out of 10 people taking INGREZZA 80 mg saw reduction in uncontrollable body movements at 6 weeks.

INGREZZA was studied in a 6-week clinical trial. A total of 234 people participated in the study. Results were based on 79 people taking the recommended dose of 80 mg.

Patients had at least a 1-point reduction on an uncontrollable movement severity scale at 6 weeks vs before treatment. This post-clinical study evaluation included 70 patients taking INGREZZA 80 mg, measuring uncontrollable movements before starting treatment and at 6 weeks of treatment.

48 weeks, Icon
48 weeks, Icon

INGREZZA showed continued improvement of TD

After 48 weeks, more than half of those taking INGREZZA reported that their uncontrolled body movements were “much improved” or “very much improved”.§

§Study evaluation at 48 weeks. 73% of patients taking INGREZZA rated their TD severity (PGIC scale) much improved/very much improved at 48 weeks vs before treatment.

Learn more about the INGREZZA clinical study

INGREZZA is different.
It’s the only treatment proven to reduce TD that’s always one capsule, once daily.
And it’s #1 prescribed.

Always 1 capsule, once daily, number 1 prescribed treatment for TD
Always 1 capsule, once daily, number 1 prescribed treatment for TD
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A lot goes into being the #1 prescribed TD treatment:

  • 27 clinical studies with over 1,470 people
  • 7 years of real-world experience
  • More than 1 million total prescriptions since 2017
  • 3 simple and effective dosing options
  • No required complex adjustment to get to an effective dose

What makes INGREZZA different?

Unlike other TD medications, INGREZZA selectively and specifically targets a protein called VMAT2. VMAT2 aids in the release of dopamine.

Based on laboratory tests. This does not imply a treatment advantage.

How INGREZZA works:

Some mental health medicines (antipsychotics) can cause abnormal dopamine signaling in the brain. This abnormal signaling can lead to uncontrollable body movements called tardive dyskinesia (TD).

Current research suggests that INGREZZA helps by correcting this abnormal dopamine signaling; however, how INGREZZA works to treat TD is not fully understood.

  1. Stage 1

    Dopamine is a chemical in the brain that helps control movement.

  2. Stage 2

    TD may be caused by too much dopamine signaling in the brain.

  3. Stage 3

    INGREZZA selectively and specifically targets VMAT2, a protein that aids in the release of dopamine…

  4. Stage 4

    …which is believed to reduce this abnormal dopamine signaling.

Based on laboratory tests. This does not imply a treatment advantage.

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With INGREZZA, you can keep takING most mental health medicines.

In a clinical study, psychiatric status remained stable overall in people taking INGREZZA for TD, including those who were also taking medicine for:

  • Depression
  • Bipolar disorder
  • Schizophrenia/schizoaffective disorder
  • Anxiety disorder

For questions about INGREZZA, call 1-84-INGREZZA (1-844-647-3992)

Did you know?
TD is unlikely to get better on its own. So, it’s important to take control and talk to your healthcare provider about treatment.

People taking INGREZZA for TD can stay on their current dose of most mental health medicines.

INGREZZA side effects

In a clinical study, the most common side effect of INGREZZA in people with tardive dyskinesia
was sleepiness.

INGREZZA may cause serious side effects, including:

  • Sleepiness
  • Heart rhythm problems
  • Abnormal movements, including shaking, body stiffness, trouble moving or walking, or keeping your balance

Other side effects include:

  • Changes in balance (balance problems, dizziness) or increased risk of falls
  • Headache
  • Feelings of restlessness
  • Dry mouth
  • Constipation
  • Blurred vision

These are not all of the possible side effects of INGREZZA.

If you experience side effects, call your healthcare provider for medical advice. To report side effects to the FDA, call 1-800-FDA-1088.

Doctor Discussion Guide
Doctor Discussion Guide

Need help talkING to your healthcare provider about your TD movements?

You can use our discussion guide to have a more productive conversation with your healthcare provider about TD and INGREZZA.

Complete the Discussion Guide
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Ready to take the next step?
Find a specialist.

You’ve worked hard to improve your mental health. Don’t let uncontrollable movements hold you back.

Take an important step forward by connecting with a psychiatry or neurology healthcare provider who has experience diagnosing and treating TD.

Find a specialist now

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