Frequently asked questions about INGREZZA and HD chorea

INGREZZA is an FDA-approved treatment for adults with the involuntary movements (chorea) of Huntington’s disease (HD).

It is not known if INGREZZA is safe and effective in children.

Do not take INGREZZA if you are allergic to valbenazine or any of the ingredients in INGREZZA.

Unlike other medications approved to treat HD chorea, INGREZZA selectively and specifically targets a protein called VMAT2.* VMAT2 is responsible for the release of dopamine.

Current research suggests that INGREZZA reduces abnormal dopamine signaling that causes HD chorea. However, how INGREZZA works to treat HD chorea is not fully understood.

* Based on laboratory tests. This does not imply a treatment advantage.

INGREZZA has been approved by the FDA for the treatment of HD chorea. Adults with mild, moderate, and severe uncontrollable body movements from HD chorea should talk to their healthcare provider about INGREZZA.

It’s important to talk to a healthcare provider about any uncontrollable movements you may be experiencing or noticing. You can use our Doctor Discussion Guide to help get the conversation started.

In a clinical study, most people began to experience improvement at 2 weeks.* Significant improvement was shown at 12 weeks vs placebo.^†

* In a post-clinical study evaluation, 51 of 64 patients (80%) taking INGREZZA 40 mg had at least a 1-point reduction in TMC score at 2 weeks vs before treatment, vs 43 of 60 (72%) for those taking placebo.

^† INGREZZA was studied in a 12-week clinical trial. A total of 128 patients participated in the study. Results were based on 64 patients taking INGREZZA 40 mg, 60 mg, or 80 mg. The primary efficacy endpoint was change in TMC from the baseline to maintenance periods.

Ask your healthcare provider to explain how INGREZZA works, when to expect results, and to clarify the goals of your treatment, including what you should look for to know if it’s working.

The most common side effects of INGREZZA or INGREZZA SPRINKLE in people with chorea associated with Huntington’s disease include sleepiness and tiredness, raised itchy red areas on your skin (hives), rash, and trouble getting to sleep or staying asleep.

These are not all of the possible side effects of INGREZZA and INGREZZA SPRINKLE. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088.

INGREZZA is the only HD chorea treatment with 3 effective strengths for simple dosing with no complex dose adjustments.

Taking INGREZZA is simple from the start:

• Starts at an effective dose
• Always one capsule, once daily
• With or without food
• Also available in sprinkle formulation
• Taken any time
• Can be added to most stable mental health regimens

• Starts at an effective dose
• Also available in sprinkle formulation
• Always one capsule, once daily
• Taken any time
• With or without food
• Can be added to most stable mental health regimens

Your healthcare provider will start you on 40 mg for 2 weeks and may increase your dosage every 2 weeks to 60 mg or 80 mg, depending on your treatment needs. The recommended dose of INGREZZA is 80 mg.

If you take too much INGREZZA, call your poison control center at 1-800-222-1222.

INGREZZA is a capsule that is taken once a day with or without food. Take INGREZZA exactly as your healthcare provider tells you.

Your healthcare provider will tell you how much INGREZZA to take and when to take it. Do not stop taking INGREZZA without talking to your healthcare provider first.

If you take too much INGREZZA, call your poison control center at 1-800-222-1222.

If you have trouble swallowing, or prefer not to swallow pills, ask your healthcare provider about INGREZZA SPRINKLE.

It works the same as INGREZZA but is available in an easy-to-open capsule with oral granules you can simply sprinkle over soft food such as applesauce, yogurt, or pudding, followed by a glass of water.

See the Instructions for Use for important information on how to take INGREZZA SPRINKLE.

Yes. The INBRACE® Support Program could help you save on your INGREZZA prescription.

$0 copay program can make INGREZZA out-of-pocket costs for eligible patients less expensive than generics.*

Additionally, if you do not have prescription coverage for INGREZZA and lack the financial resources to pay for the medicine, you may be able to receive your prescription at no cost through the INGREZZA Patient Assistance Program.^† Your healthcare provider can help you apply for the program or call 1-84-INGREZZA (1-844-647-3992) to learn more.

* This offer is valid only for patients who have commercial (nongovernment-funded) insurance. Additional terms and conditions apply.

^† This program is not contingent on a purchase of any kind. Product dispensed under this free trial program may not be submitted for reimbursement to any third-party payer. We reserve the right to modify or cancel the program at any time.

You are NOT required to change therapy at your insurance company’s request, even if you received a letter from them requesting that you try a different therapy than INGREZZA.

The most important thing you can do is talk to your doctor and share your experience taking INGREZZA. You can also call 1-84-INGREZZA (1-844-647-3992), 8 am to 8 pm, Monday through Friday, for additional assistance.

Call or email your healthcare provider (if it’s an option) and ask them to repeat any information you didn’t understand at your appointment or to explain it differently—they may not realize they might be using confusing, scientific terms.

Also, consider including a family member, caregiver, or friend to join you at your next appointment. They can help you better understand and remember your healthcare provider’s advice and instructions.

The Huntington’s Disease Society of America (HDSA) can connect patients and families to social workers who can help navigate the challenges of living with HD chorea.

There’s community and support for HD chorea patients and caregivers.

Are you or a loved one taking INGREZZA to treat HD chorea? Do you have an interest in sharing your story? If you’re a US resident and 18 years or older, please complete this form or call 1-844-814-5376 to find out if you are eligible to participate in our Patient Ambassador Program. Any information you provide will be kept in accordance with our privacy policy.

Please note that not all candidates will be selected to participate in the program.